Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis.
Enrique de MadariaJames L BuxbaumPatrick MaisonneuveAna García García de ParedesPedro ZapaterLucía GuilabertAlicia Vaillo-RocamoraMiguel Ángel Rodriguez-GandíaJesús Donate-OrtegaEdgard E Lozada-HernándezAlan J R Collazo MorenoAlba Lira-AguilarLaura P LlovetRajiv MehtaRaj TandelPablo NavarroAna M Sánchez-PardoClaudia Sánchez-MarinMarina CobrerosIdaira Fernández-CabreraFernando Casals-SeoaneDiego Casas DezaEugenia Lauret-BrañaEva Martí-MarquésLaura M Camacho-MontañoVerónica UbietoMikel GanuzaFederico Boladonull nullPublished in: The New England journal of medicine (2022)
In this randomized trial involving patients with acute pancreatitis, early aggressive fluid resuscitation resulted in a higher incidence of fluid overload without improvement in clinical outcomes. (Funded by Instituto de Salud Carlos III and others; WATERFALL ClinicalTrials.gov number, NCT04381169.).