Physical separation of haplotypes in dikaryons allows benchmarking of phasing accuracy in Nanopore and HiFi assemblies with Hi-C data.

Hongyu DuanAshley W JonesTim HewittAmy MackenzieYiheng HuAnna SharpDavid LewisRohit MagoNarayana M UpadhyayaJohn P RathjenEric A StoneBenjamin SchwessingerMelania FigueroaPeter N DoddsSambasivam PeriyannanJana Sperschneider

Published in: Genome biology (2022)

This first Hi-C based phasing pipeline for dikaryons and comparison of long-read sequencing technologies will inform future genome assembly and haplotype phasing projects in other non-haploid organisms.

Keyphrases

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