Targeting epidermal growth factor receptor to recruit newly generated neuroblasts in cortical brain injuries.
Ricardo Gómez-OlivaNoelia Geribaldi-DoldánSamuel Domínguez-GarcíaRicardo Pardillo-DíazSergio Martínez-OrtegaJosé M Oliva-MonteroPatricia Pérez-GarcíaFrancisco J García-CózarJuan P Muñoz-MirandaIsmael Sánchez-GomarPedro Nunez-AbadesCarmen CastroPublished in: Journal of translational medicine (2023)
Our results indicate that in response to an injury, microglial cells activated within the injury and the SVZ release TGF-α, activating the EGFR present in the neuroblasts membrane inducing their proliferation, delaying maturation and negatively regulating migration. The inactivation of this signaling pathway stimulates neuroblast migration toward the injury and enhances the quantity of neuroblasts within the injured area. These results suggest that these proteins may be used as target molecules to regenerate brain injuries.
Keyphrases
- epidermal growth factor receptor
- signaling pathway
- induced apoptosis
- tyrosine kinase
- advanced non small cell lung cancer
- resting state
- white matter
- small cell lung cancer
- epithelial mesenchymal transition
- inflammatory response
- functional connectivity
- multiple sclerosis
- oxidative stress
- endoplasmic reticulum stress
- cell proliferation
- spinal cord injury
- transforming growth factor
- cerebral ischemia
- lps induced
- drug delivery
- neuropathic pain
- spinal cord