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Catalyst-Free gem-Difunctionalization of Fluoroalkyl-Substituted Diazo Compound with Diselenide or Disulfide and NFSI.

Jiuling LiChaoqun MaDong XingWenhao Hu
Published in: Organic letters (2019)
The gem-difunctionalization of fluoroalkyl-substituted diazo compounds by utilizing diselenides or disulfides and NFSI under catalyst-free and mild conditions is reported. A series of gem-aminoselenolation and gem-aminosulfonylation products bearing fluoroalkyl substituents were obtained in high to excellent yields. Different types of conjugated diazo compounds are also applicable to this transformation. Preliminary mechanistic studies indicate that a selenoimidate intermediate generated from diselenide and NFSI is involved for this transformation.
Keyphrases
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