Androgen alleviates neurotoxicity of β-amyloid peptide (Aβ) by promoting microglial clearance of Aβ and inhibiting microglial inflammatory response to Aβ.
Peng-Le YaoShu ZhuoHong MeiXiao-Fang ChenNa LiTeng-Fei ZhuShi-Ting ChenJi-Ming WangRui-Xing HouYing-Ying LePublished in: CNS neuroscience & therapeutics (2017)
Our study demonstrates that androgen promotes microglia to phagocytose and clear Aβ42 and inhibits Aβ42 -induced inflammatory response, which may play an important role in reducing the neurotoxicity of Aβ.