Conservation of immune gene signatures in solid tumors and prognostic implications.
Julia ChifmanAshok PullikuthJeff W ChouDavide BedognettiLance D MillerPublished in: BMC cancer (2016)
These findings suggest that tumor infiltrating immune cells can be differentiated by immune-specific gene expression patterns that quantify the relative abundance of multiple immune infiltrates across a range of solid tumor types. That these markers of immune involvement are significantly associated with patient prognosis in diverse cancers suggests their clinical utility as pan-cancer markers of tumor behavior and immune responsiveness.