Persistent SARS-CoV-2 infection with accumulation of mutations in a patient with poorly controlled HIV infection.

Tongai Gibson MapongaMontenique JeffriesHouriiyah TegallyAndrew SutherlandEduan WilkinsonRichard J LessellsNokukhanya MsomiGert U van Zyl Tulio de OliveiraWolfgang Preiser

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)

A 22-year-old female with uncontrolled advanced HIV infection was persistently infected with SARS-CoV-2 beta variant for 9 months, the virus accumulating >20 additional mutations. Antiretroviral therapy suppressed HIV and cleared SARS-CoV-2 within 6-9 weeks. Increased vigilance is warranted to benefit affected individuals and prevent the emergence of novel SARS-CoV-2 variants.

Keyphrases

sars cov
antiretroviral therapy
hiv infected
respiratory syndrome coronavirus
hiv positive
human immunodeficiency virus
hiv infected patients
hiv aids
coronavirus disease
copy number
gene expression
south africa