Leptin Decreases Energy Expenditure Despite Increased Thyroid Hormone in Patients With Lipodystrophy.
Andrew GroverEmmanuel QuayeRobert J BrychtaJohn ChristensenMegan S StartzellCristina Adelia MeehanAreli ValenciaBrandon MarshallKong Y ChenRebecca J BrownPublished in: The Journal of clinical endocrinology and metabolism (2021)
Metreleptin initiation decreased EE in patients with lipodystrophy, but no changes were observed after metreleptin withdrawal. Thyroid hormone was higher on metreleptin in both initiation and withdrawal cohorts. Decreased EE after metreleptin in lipodystrophy may result from reductions in energy-requiring metabolic processes that counteract increases in EE via adipose tissue-specific neuroendocrine and adrenergic signaling.
Keyphrases