Inflammation, a significant player of Ataxia-Telangiectasia pathogenesis?

Majid Zaki-DizajiSeyed Mohammad AkramiGholamreza AziziHassan AbolhassaniAsghar Aghamohammadi

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2018)

Ataxia-Telangiectasia Mutated (ATM), a master regulator of the DNA damage response is the protein known to be associated with A-T and has a complex nuclear and cytoplasmic role. Loss of ATM function may induce immune deregulation and systemic inflammation.

Keyphrases

dna damage response
dna repair
early onset
oxidative stress
transcription factor
protein protein
small molecule
cell fate