Vitamin D deficiency and clinical correlations in systemic sclerosis patients: A retrospective analysis for possible future developments.
Amelia Chiara TrombettaVanessa SmithEmanuele GotelliMassimo GhioSabrina PaolinoCarmen PizzorniAmber VanhaeckeBarbara RuaroAlberto SulliMaurizio CutoloPublished in: PloS one (2017)
Serum 25(OH)D deficiency was found to correlate with lung involvement, peripheral vascular, kidney and gastrointestinal Medsger's DSS parameters and with seasonality In SSc patients. Supplementation with oral colecalciferol was found not effective in increasing 25(OH)D serum concentrations. Therefore, for successful replacement, supra-physiological vitamin D3 doses or programmed UVB light exposure should be tested.