Efficient Lead Finding, Activity Enhancement and Preliminary Selectivity Control of Nuclear Receptor Ligands Bearing a Phenanthridinone Skeleton.

Yuko NishiyamaShinya FujiiMakoto MakishimaYuichi HashimotoMinoru Ishikawa

Published in: International journal of molecular sciences (2018)

Our approach proved effective for efficient lead finding, activity enhancement and preliminary control of selectivity over other receptors. The phenanthridinone skeleton appears to be a promising steroid surrogate.

Keyphrases

structural basis
binding protein