Deficient Rnf43 potentiates hyperactive Kras-mediated pancreatic preneoplasia initiation and malignant transformation.

Xian ZhouZhichao SunMengdi ZhangXiaoyu QuShuhui YangLianmei WangYanling JingLi LiWeiwei DengFangming LiuJin DiJie ChenJian WuHongbing Zhang

Published in: Animal models and experimental medicine (2022)

preclinical cancer model recapitulates the pathological process from pancreatic cyst to cancer in humans and can be treated with inhibitors of Wnt/β-catenin signaling. Since the presence of RNF43 and KRAS mutations in IPMNs predicts future development of advanced neoplasia from PCLs, patients with these genetic anomalies warrant surveillance, surgery, and/or targeted therapeutics such as Wnt/β-catenin inhibitors.

Keyphrases

papillary thyroid
cell proliferation
stem cells
squamous cell
minimally invasive
wild type
public health
epithelial mesenchymal transition
lymph node metastasis
gene expression
genome wide
current status
copy number
dna damage
mesenchymal stem cells
atrial fibrillation
young adults