Thrombopoietin mimetic stimulates bone marrow vascular and stromal niches to mitigate acute radiation syndrome.
Justin VercellinoBeata MałachowskaShilpa KulkarniBrett I BellShahin ShajahanKosaku ShinodaGary EichenbaumAmit K VermaSanchita P GhoshWeng-Lang YangPaul S FrenetteChandan GuhaPublished in: Research square (2024)
TPOm interacts with BM vascular and stromal niches to locally support hematopoietic reconstitution and systemically improve survival in mice after TBI. Therefore, this work warrants the development of TPOm as a potent radiation MCM for the treatment of ARS.
Keyphrases
- bone marrow
- mesenchymal stem cells
- traumatic brain injury
- liver failure
- respiratory failure
- radiation induced
- drug induced
- high fat diet induced
- case report
- free survival
- radiation therapy
- hepatitis b virus
- insulin resistance
- skeletal muscle
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- replacement therapy