Conditional knockout of AIM2 in microglia ameliorates synaptic plasticity and spatial memory deficits in a mouse model of Alzheimer's disease.

Lei YeMengsha HuRui MaoYi TanMin SunJunqiu JiaSiyi XuYi LiuXiao-Lei Zhu Yun Xu Feng Bai Shu Shu

Published in: CNS neuroscience & therapeutics (2023)

Our results demonstrated that microglial AIM2 plays a critical role in regulating synaptic plasticity and memory deficits associated with AD, providing a new direction for developing novel preventative and therapeutic interventions for this disease.

Keyphrases

mouse model
traumatic brain injury
inflammatory response
working memory
neuropathic pain
physical activity
lipopolysaccharide induced
lps induced
spinal cord