The first cohort of Iranian patients with hyper immunoglobulin E syndrome: A long-term follow-up and genetic analysis.

Mahmood TavassoliHassan AbolhassaniReza YazdaniMohsen GhadamiGholamreza AziziSina Abdolrahim Poor HeraviTannaz Moeini ShadMostafa KokabeeMasoud MovahediHormoz AbdshahzadehMohammad GharagozlouNima RezaeiHossein EsmaeilzadehSoheila AleyasinAsghar Aghamohammadi

Published in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2019)

Specific molecular study of STAT3 and DOCK8 mutations in patients with HIES clinical phenotype could help the physician to definitively characterize the disease. Since HIES showed the highest rate of unsolved combined immunodeficiency, investigation of other genetic and environmental factors could also help in understanding the mechanism of remaining patients as well as providing strategy into therapeutic modalities.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
emergency department
primary care
cell proliferation
copy number
dna methylation