In premenopausal women with idiopathic osteoporosis, lower bone formation rate is associated with higher body fat and higher IGF-1.

T G GoetzN NairS ShiauR R ReckerJ M LappeD W DempsterH ZhouB ZhaoX GuoW ShenT L NickolasM Kamanda-KossehM BucovskyJ StubbyE ShaneAdi Cohen

Published in: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2021)

Paradoxical IGF-1 relationships suggest that abnormal or atypical regulation of bone and fat may contribute to osteoporosis mechanisms in premenopausal IOP.

Keyphrases

postmenopausal women
bone mineral density
pi k akt
binding protein
growth hormone
adipose tissue
body composition
cell proliferation
signaling pathway
early breast cancer
breast cancer risk
bone regeneration