Retinotopic degeneration of the retina and optic tracts in autosomal dominant Alzheimer's disease.

Suman AdhikariYuchuan QiaoMaxwell SingerAbhay SagareXuejuan JiangYonggang ShiJohn M RingmanAmir H Kashani

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)

In ADAD, GCIPL thickness is significantly associated with retinotopic optic tract DTI measures even in minimally symptomatic subjects. Similar associations were not present with ONL thickness or when ignoring retinotopy. We provide in vivo evidence for optic tract changes resulting from ganglion cell pathology in ADAD.

Keyphrases

optical coherence tomography
optic nerve
diabetic retinopathy
single cell
cell therapy
multiple sclerosis
stem cells