Epigenome-wide association study shows differential DNA methylation of MDC1, KLF9 and CUTA in autoimmune thyroid disease.

Nicole Lafontaine Christopher J Shore Purdey J Campbell Benjamin H Mullin Suzanne J Brown Vijay Panicker Frank Dudbridge Thomas H Brix Laszlo Hegedüs Scott G Wilson Jordana T Bell John P Walsh

Published in: The Journal of clinical endocrinology and metabolism (2023)

Our study reveals differences in DNAm between GD and HD, which may help explain why some people develop GD and others HD and provide a link to environmental risk factors. Additional research is needed to advance understanding of the role of DNAm in AITD and investigate its prognostic and therapeutic potential.

Keyphrases

dna methylation
risk factors
genome wide
multiple sclerosis
transcription factor
risk assessment
nk cells
climate change