Gadolinium-Decorated Silica Microspheres as Redox-Responsive MRI Probes for Applications in Cell Therapy Follow-Up.
Monica Muñoz ÚbedaFabio CarniatoValeria CatanzaroSergio PadovanCristina GrangeStefano PortaCarla CarreraLorenzo TeiGiuseppe DigilioPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2016)
The redox microenvironment within a cell graft can be considered as an indicator to assess whether the graft is metabolically active or hypoxic. We present a redox-responsive MRI probe based on porous silica microparticles whose surface has been decorated with a Gd-chelate through a disulphide bridge. Such microparticles are designed to be interspersed with therapeutic cells within a biocompatible hydrogel. The onset of reducing conditions within the hydrogel is paralleled by an increased clearance of Gd, that can be detected by MRI.
Keyphrases
- cell therapy
- contrast enhanced
- magnetic resonance imaging
- stem cells
- diffusion weighted imaging
- drug delivery
- quantum dots
- induced apoptosis
- mesenchymal stem cells
- tissue engineering
- living cells
- computed tomography
- hyaluronic acid
- magnetic resonance
- wound healing
- reduced graphene oxide
- small molecule
- cell cycle arrest
- ionic liquid
- electron transfer
- signaling pathway
- gold nanoparticles
- oxidative stress
- endoplasmic reticulum stress
- fluorescent probe
- tandem mass spectrometry