Downregulation of gene expression in hypoxic cancer cells by an activatable G-quadruplex stabiliser.

Busra UyarNezahat Gokce OzsamurFatma Secer CelikIlkyaz OzbayramSundus Erbas-Cakmak

Published in: Chemical communications (Cambridge, England) (2023)

In the research, the modulation of gene expression with a novel G-quadruplex stabiliser was analysed. Activation by the removal of bulky hypoxia-responsive substituent enhances G-quadruplex stabilisation. Hypoxic MCF7 cells incubated with the stabiliser displayed significant downregulation of oncogenes c-myc, bcl-2, and hif-1α. This study presents the first hypoxia-activatable G-quadruplex stabilization and transcriptional regulation.

Keyphrases

gene expression
dna methylation
endothelial cells
induced apoptosis
signaling pathway
cell proliferation
fluorescence imaging
cell cycle arrest
breast cancer cells
oxidative stress
cell death
cancer therapy
photodynamic therapy
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