Intracellular inflammatory and antioxidant pathways in postmortem frontal cortex of subjects with major depression: effect of antidepressants.
David Martín-HernándezJavier R CasoJ Javier MeanaLuis F CalladoJosé L M MadrigalBorja García-BuenoJuan C LezaPublished in: Journal of neuroinflammation (2018)
Data indicate an altered TLR-4 immune response in the brain of subjects with MDD. Additional research focused on the mechanisms contributing to the antidepressant-induced TLR-4 pathway modulation is warranted and could help to develop new treatment strategies for MDD.
Keyphrases
- major depressive disorder
- immune response
- toll like receptor
- functional connectivity
- resting state
- bipolar disorder
- oxidative stress
- inflammatory response
- diabetic rats
- high glucose
- dendritic cells
- electronic health record
- white matter
- nuclear factor
- big data
- anti inflammatory
- reactive oxygen species
- drug induced
- machine learning
- multiple sclerosis
- data analysis