Immunohistochemical detection of p53 and pp53 Ser392 in canine hemangiomas and hemangiosarcomas located in the skin.
María José García-IglesiasJose Luis Cuevas-HigueraAna Bastida-SáenzMaría Gracia de Garnica-GarcíaLaura PolledoPaula PereroJorge González-FernándezBeatriz Fernández-MartínezClaudia Pérez-MartínezPublished in: BMC veterinary research (2020)
The p53 and phospho-p53 Serine392overexpression together with high proliferative activity in hemangiosarcomas versus hemangiomas indicated that p53 might play a role in the acquisition of malignant phenotypes in cutaneous endothelial neoplasms in dogs. The Ki-67 index may be useful in distinguishing canine well-differentiated hemangiosarcomas from hemangiomas.