Molecular profile of nasopharyngeal carcinoma: analysing tumour suppressor gene promoter hypermethylation by multiplex ligation-dependent probe amplification.
Marc Lucas OoftJolique van IpenburgRob van LooRick de JongCathy MoelansWeibel BrauniusRemco de BreePaul van DiestSenada KoljenovićRob J Baatenburg de JongJose HardilloStefan M WillemsPublished in: Journal of clinical pathology (2017)
There are important epigenetic differences between EBV-negative and EBV-positive NPCs, with EBV-negative NPC having a more similar hypermethylation profile to other head and neck squamous cell carcinomas than EBV-positive NPC. Hypermethylation of RASSF1A might contribute to worse OS in EBV-positive NPC, and may be an important event in the pathogenesis of EBV-infected NPC. Hypermethylation of APC might contribute to worse DFS in EBV-negative NPC.