The role of exosomal lncRNAs in cancer biology and clinical management.
Wu-Wen ZhangQinshi WangYi YangSiyuan ZhouPing ZhangTongbao FengPublished in: Experimental & molecular medicine (2021)
Exosomes play a vital role in cell-cell communication within the cancer microenvironment. Exosomal long noncoding RNAs (lncRNAs) are important regulators in cancer development and are involved in multiple processes, including cancer cell proliferation, angiogenesis, metastasis, drug resistance, and immunomodulation. Changes in the levels of exosomal lncRNAs often appear with the occurrence and development of cancer. Therefore, exosomal lncRNAs can be used as biomarkers for cancer diagnosis and prognosis. Exosomal lncRNAs can also indicate the treatment response of patients receiving chemotherapy. Moreover, exosomal lncRNAs are potential therapeutic targets for cancer treatment. In this review, we summarize the role of exosomal lncRNAs in cancer biology as well as in clinical management. A more comprehensive and in-depth understanding of the role of exosomal lncRNAs in cancer may help us better understand the mechanism of cancer development and clinically manage cancer patients.
Keyphrases
- papillary thyroid
- squamous cell
- cell proliferation
- stem cells
- lymph node metastasis
- childhood cancer
- risk assessment
- squamous cell carcinoma
- single cell
- climate change
- young adults
- cell cycle
- transcription factor
- endothelial cells
- locally advanced
- vascular endothelial growth factor
- optical coherence tomography
- genome wide analysis