Downregulated INHBB in endometrial tissue of recurrent implantation failure patients impeded decidualization through the ADCY1/cAMP signalling pathway.

Hui ZhangZhilong WangQuan ZhouZhiwen CaoYue JiangManlin XuJingyu LiuJidong ZhouGui-Jun YanHaixiang Sun

Published in: Journal of assisted reproduction and genetics (2023)

The decline of INHBB in HESCs suppressed ADCY1-induced cAMP production and cAMP-mediated signalling, which attenuated decidualization in RIF patients, indicating that INHBB is an essential component in the decidualization process.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
mycobacterium tuberculosis
patient reported outcomes
endometrial cancer
protein kinase