Risk of type 2 diabetes mellitus by antimuscarinic agents among adult females receiving care in the military health system.

Daniel J SeligAaron J BrownJesse P DeLucaAdrian T KressJeffrey R LivezeyThomas G OliverElaine D PorRosenie Thelus Jean

Published in: Pharmacoepidemiology and drug safety (2020)

We found exposure to M3 selective antagonists darifenacin and solifenacin had the highest risk of developing T2DM compared to nonselective antagonist oxybutynin. This is supported by well described physiologic mechanisms and may allow for more informed prescribing decisions, particularly if minimizing risk of T2DM is a priority.

Keyphrases

glycemic control
primary care
healthcare
palliative care
type diabetes
quality improvement
pain management
insulin resistance
emergency department
cardiovascular risk factors
young adults
skeletal muscle
metabolic syndrome