Antidepressants and type 2 diabetes: highways to knowns and unknowns.
Nahi Sabih AlruwailiHayder M Al-KuraishyAli I Al-GareebAli K AlbuhadilyAmany Elsayed RagabAhmad Awad AlenaziAthanasios AlexiouMarios PapadakisGaber El-Saber BatihaPublished in: Diabetology & metabolic syndrome (2023)
Type 2 diabetes (T2D) is a metabolic disease caused by the development of insulin resistance (IR), relative insulin deficiency, and hyperglycemia. Hyperglycemia-induced neurochemical dysregulation activates the progression of depression in T2D patients. Therefore, management of depression by antidepressant agents improves glucose homeostasis and insulin sensitivity. However, prolong use of antidepressant drugs may increase the risk for the development of T2D. However, there is strong controversy concerning the use of antidepressant drugs in T2D. Therefore, this review try to elucidate the potential effects of antidepressant drugs in T2D regarding their detrimental and beneficial effects.
Keyphrases
- type diabetes
- major depressive disorder
- insulin resistance
- glycemic control
- bipolar disorder
- end stage renal disease
- diabetic rats
- depressive symptoms
- ejection fraction
- chronic kidney disease
- drug induced
- cardiovascular disease
- metabolic syndrome
- blood glucose
- peritoneal dialysis
- adipose tissue
- high glucose
- climate change
- endothelial cells
- physical activity
- human health