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Massive tramadol ingestion resulting in fatal brain injury - a pharmacokinetic study with discussion on the involved mechanisms of toxicity.

Alicja PuszkielIsabelle MalissinSalvatore CisterninoNicolas PalletXavier DeclèvesBruno Mégarbane
Published in: Clinical toxicology (Philadelphia, Pa.) (2022)
Massive tramadol ingestion with prolonged high plasma concentrations can result in severe brain injury, possibly involving vasospasm.
Keyphrases
  • brain injury
  • subarachnoid hemorrhage
  • cerebral ischemia
  • oxidative stress
  • early onset
  • drug induced