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HIF-1 transcription activity: HIF1A driven response in normoxia and in hypoxia.

Flora CimminoMarianna AvitabileVito Alessandro LasorsaAnnalaura MontellaLucia PezoneSueva CantalupoFeliciano VisconteMaria Valeria CorriasAchille IolasconMario Capasso
Published in: BMC medical genetics (2019)
These findings may help to understand the molecular mechanisms by which low oxygen levels reshape gene signatures and provide new direction for hypoxia targeting in solid tumor.
Keyphrases
  • endothelial cells
  • genome wide
  • copy number
  • cancer therapy
  • dna methylation
  • genome wide identification
  • drug delivery