Presence of autoantibodies in serum does not impact the occurrence of immune checkpoint inhibitor-induced hepatitis in a prospective cohort of cancer patients.

Mette-Triin PurdeRebekka NiedererNikolaus B WagnerStefan DiemFiamma BernerOmar Hasan AliDorothea HillmannIrina BergaminMarkus JoergerMartin RischChristoph NiederhauserTobias L LenzMartin FrühLorenz RischDavid SemelaLukas Flatz

Published in: Journal of cancer research and clinical oncology (2021)

We found nominally significant associations of ICI-induced hepatitis with two HLA alleles. ICI-induced hepatitis showed no correlation with liver-specific autoantibodies, but frequently co-occurred with irAEs affecting other organs. Unlike other irAEs, ICI-induced hepatitis is not associated with a better prognosis.

Keyphrases

high glucose
diabetic rats
drug induced
oxidative stress
endothelial cells