Progression of Frailty in Survivors of Childhood Cancer: A St. Jude Lifetime Cohort Report.
Angela DelaneyCarrie R HowellKevin R KrullTara M BrinkmanGregory T ArmstrongWassim ChemaitillyCarmen L WilsonDaniel A MulrooneyZhaoming WangJennifer Q LanctotRuth E JohnsonMatthew R KrullRobyn E PartinKyla C SheltonDeo Kumar SrivastavaLeslie L RobisonMelissa M HudsonKristen K NessPublished in: Journal of the National Cancer Institute (2022)
Prevalent frailty more than doubled at 5 years after study entry among adult childhood cancer survivors. Frailty at entry was the strongest risk factor for death. Because treatment exposures cannot be changed, mitigation of other risk factors for frailty, including lack of strength training and sedentary lifestyle, may decrease risk of adverse health events and improve longevity in survivors.