Cardiomyopathy, oxidative stress and impaired contractility in a rheumatoid arthritis mouse model.
Gianluigi PirontiAlex Bersellini-FarinottiNilesh M AgalaveKatalin SandorTeresa Fernandez-ZafraAlexandra JurczakLars H LundCamilla I SvenssonDaniel C AnderssonPublished in: Heart (British Cardiac Society) (2018)
This study shows that inflammation during active RA has long-term consequences on molecular remodelling and contractile function of the heart, which further supports that rheumatology patients should be followed for development of heart failure.
Keyphrases
- heart failure
- oxidative stress
- rheumatoid arthritis
- mouse model
- end stage renal disease
- ejection fraction
- chronic kidney disease
- disease activity
- newly diagnosed
- skeletal muscle
- atrial fibrillation
- ankylosing spondylitis
- dna damage
- peritoneal dialysis
- smooth muscle
- left ventricular
- systemic lupus erythematosus
- ischemia reperfusion injury
- patient reported outcomes
- induced apoptosis
- systemic sclerosis
- juvenile idiopathic arthritis
- endoplasmic reticulum stress