A rare immunological disease, caspase 8 deficiency: case report and literature review.

Narges BazgirAzin TahvildariZahra ChavoshzadeMahnaz JameeZahra GolchehreAbdollah KarimiNaghi DaraMazdak FallahiMohammad KeramatipourArezou KaramzadeSamin Sharafian

Published in: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology (2023)

There can be diarrhea or dysentery as the first or main symptoms of inborn errors of immunity (IEIs). The cause of diarrhea and dysentery in this case was early-onset IBD. One of the symptoms of IEIs such as caspase-8 deficiency is early-onset of IBD. Patients with early-onset had normal T cell count and low or normal immunoglobulin levels with insufficient immune response.

Keyphrases

early onset
late onset
immune response
cell death
clostridium difficile
irritable bowel syndrome
induced apoptosis
sleep quality
replacement therapy
patient safety
dendritic cells
depressive symptoms
emergency department
adverse drug
smoking cessation
inflammatory response
quality improvement
signaling pathway