Causal Relationship between Gut Microbiota, Metabolites, and Sarcopenia: A Mendelian Randomization Study.

Utilizing a two-sample MR approach, our study elucidates the causal interplay among gut microbiota, gut microbiota-derived metabolites, and the occurrence of sarcopenia. These findings suggest that gut microbiota and metabolites may represent a potential underlying risk factor for sarcopenia, and offer the promise of novel therapeutic focal points.