Substance P-induced lung inflammation in mice is mast cell dependent.

Nan WangJue WangYongjing ZhangShiling HuTianxiao ZhangYuanyuan WuXiuzhen SunTao ZhangShuanying YangLangchong He

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2021)

Substance P levels increased significantly in serum of asthmatic patients and independently associated with the risk of asthma. Furthermore, SP induced Th2 lung inflammation in mice, which was dependent on MCs.

Keyphrases

oxidative stress
diabetic rats
high glucose
end stage renal disease
ejection fraction
high fat diet induced
newly diagnosed
lung function
chronic kidney disease
chronic obstructive pulmonary disease
drug induced
adipose tissue
skeletal muscle
cystic fibrosis
wild type