Clinical, Neuroimaging, and Genetic Markers in Cerebral Amyloid Angiopathy-Related Inflammation: A Systematic Review and Meta-Analysis.
Aikaterini TheodorouLina PalaiodimouKonark MalhotraChristina ZompolaAristeidis H KatsanosAshkan ShoamaneshEfstathios BoviatsisEfthimios DardiotisMartha SpiliotiSimona SaccoDavid John WerringCharlotte CordonnierAndrei V AlexandrovGeorgios P ParaskevasGeorgios K TsivgoulisPublished in: Stroke (2022)
Cognitive decline was the most common clinical feature. Hyperintense T2/fluid-attenuated inversion recovery white matter lesions and lobar cerebral microbleeds were by far the most prevalent neuroimaging findings. Thirty-four percent of patients with CAA-ri have homozygous ApoE ε4/ε4 genotype and scarce data exist regarding the cerebrospinal fluid biomarkers and its significance in these patients.
Keyphrases
- cognitive decline
- mild cognitive impairment
- white matter
- cerebrospinal fluid
- end stage renal disease
- subarachnoid hemorrhage
- newly diagnosed
- ejection fraction
- chronic kidney disease
- oxidative stress
- machine learning
- peritoneal dialysis
- type diabetes
- gene expression
- genome wide
- big data
- cerebral ischemia
- computed tomography
- dna methylation
- patient reported outcomes
- artificial intelligence
- blood brain barrier