Changes in the Selected Antioxidant Defense Parameters in the Blood of Patients after High Resolution Computed Tomography.
Amira BryllWirginia KrzyściakAnna JurczakRobert ChrzanAnna LizońAndrzej UrbanikPublished in: International journal of environmental research and public health (2019)
Ionizing radiation generated during high resolution computed tomography (HRCT) scanning may have an indirect effect on the mechanisms regulating the oxidative-antioxidant balance in the human body, which is one of the necessary factors ensuring the maintenance of its homeostasis. The aim of the study was to analyze the response of antioxidant systems through the determination of the antioxidant markers in the blood of patients exposed to oxidative stress resulting from the routine HRCT examination of the chest. Blood of 35 people aged 60.77 ± 10.81 taken before and at four time points after the examination constituted the test material. The determination of the total antioxidant capacity expressed as ferric reducing ability of plasma (FRAP) and ferric reducing antioxidant activity and ascorbic acid concentration (FRASC) were performed together with an examination of catalase activity and the concentration of the reduced glutathione. The organism's response to ionizing radiation was associated with a significant decrease in the antioxidant markers' levels at all time-points and showed a significant negative correlation depending on the radiation dose. Visible down-regulation of these markers is a response to increased oxidative stress. In light of the obtained results, the measurement of the selected markers of antioxidant defense may be a useful parameter of oxidative stress caused by ionizing radiation.
Keyphrases
- oxidative stress
- high resolution
- computed tomography
- anti inflammatory
- end stage renal disease
- dna damage
- newly diagnosed
- ejection fraction
- induced apoptosis
- chronic kidney disease
- ischemia reperfusion injury
- endothelial cells
- magnetic resonance imaging
- prognostic factors
- positron emission tomography
- mass spectrometry
- patient reported outcomes
- tandem mass spectrometry
- clinical practice
- molecularly imprinted
- liquid chromatography
- patient reported
- iron deficiency