A nomogram to predict pathologic complete response (pCR) and the value of tumor-infiltrating lymphocytes (TILs) for prediction of response to neoadjuvant chemotherapy (NAC) in breast cancer patients.
Hye Won HwangHera JungJiyeon HyeonYeon Hee ParkJin Seok AhnYoung-Hyuck ImSeok Jin NamSeok Won KimJeong Eon LeeJong-Han YuSe Kyung LeeMisun ChoiSoo Youn ChoEun Yoon ChoPublished in: Breast cancer research and treatment (2018)
High pre-NAC TIL levels were significantly predictive of pCR in BC, and can act as a surrogate marker for predicting therapeutic effects of a TCHP regimen for HER2-positive BC. Post-NAC TILs in residual disease were a new prognostic marker of risk stratification for long-term survival.