The amyloid-β pathway in Alzheimer's disease: a plain language summary.
Harald HampelYan HuJohn HardyKaj BlennowChristopher ChenGeorge PerrySeung Hyun KimVictor L VillemagnePaul AisenMichele VendruscoloTakeshi IwatsuboColin L MastersMin ChoLars LannfeltJeffrey L CummingsAndrea VergalloPublished in: Neurodegenerative disease management (2023)
The physiological balance of brain Aβ levels in the context of AD is complex. Despite many unanswered questions, mounting evidence indicates that Aβ has a central role in driving AD progression. A better understanding of the Aβ pathway biology will help identify the best therapeutic targets for AD and inform treatment approaches.