Extracts from Argentinian native plants reverse fluconazole resistance in Candida species by inhibiting the efflux transporters Mdr1 and Cdr1.

Florimar GilJerónimo LaioloBrayan Bayona-PachecoRichard David CannonAntonio Ferreira-PereiraMaría Cecilia Carpinella

Published in: BMC complementary medicine and therapies (2022)

The non-toxic and highly active extracts from A. communis and S. atripicifolium, provide promising sources of compounds for potentiating the antifungal effect of FCZ by blocking the efflux function of Mdr1 and Cdr1 transporters.

Keyphrases

candida albicans
multidrug resistant
biofilm formation
signaling pathway
staphylococcus aureus