BPTF in bone marrow provides a potential progression biomarker regulated by TFAP4 through the PI3K/AKT pathway in neuroblastoma.
Chiyi JiangYeran YangSidou HeZhixia YueTianyu XingPing ChuWenfa YangHui ChenXiaoxi ZhaoYongbo YuXuan ZhangYan SuYongli GuoXiaoli MaPublished in: Biological procedures online (2023)
A novel and convenient BPTF-targeted humoral detection that can prompt minimal residual and predict NB progression in the early stages of the disease were identified. BPTF inhibitor AU1 is expected to become a new targeted drug for NB therapy. It's also reveal previously unknown mechanisms of BPTF in NB cell proliferation and metastasis through TFAP4 and PI3K/AKT pathways.
Keyphrases
- pi k akt
- cell proliferation
- signaling pathway
- bone marrow
- cell cycle arrest
- cancer therapy
- immune response
- cell cycle
- mesenchymal stem cells
- genome wide
- sensitive detection
- emergency department
- risk assessment
- stem cells
- single cell
- cell death
- drug delivery
- gold nanoparticles
- dna methylation
- smoking cessation
- reduced graphene oxide
- electronic health record