Biological significance of MYC and CEBPD coamplification in urothelial carcinoma: Multilayered genomic, transcriptional and posttranscriptional positive feedback loops enhance oncogenic glycolysis.

Ti-Chun ChanYi-Ting ChenKien Thiam TanChia-Ling WuWen-Jeng WuWei-Ming LiJu-Ming WangYow-Ling ShiueChien-Feng Li

Published in: Clinical and translational medicine (2022)

We confirmed that CEBPD has an oncogenic role in UC by activating AKT signalling and initiating metabolic reprogramming from mitochondrial oxidative phosphorylation to glycolysis to satisfy glucose addiction. These novel CEBPD- and MYC-centric multilayered positive feedback loops enhance cancer growth that could complement theranostic approaches.

Keyphrases

transcription factor
signaling pathway
papillary thyroid
oxidative stress
photodynamic therapy
cell proliferation
gene expression
squamous cell
copy number
blood glucose
adipose tissue
fluorescence imaging
dna methylation