Galectin-9 Levels as a Potential Predictor of Intact HIV Reservoir Decay.
Sergio Serrano-VillarAkshay GalaPeter BacchettiRebecca HohClara di GermanioLillian B CohnTimothy J HenrichPeter W HuntGregory M LairdSatish K PillaiSteven G DeeksMichael J PelusoPublished in: The Journal of infectious diseases (2024)
The pronounced association between baseline Gal-9 levels and subsequent intact HIV decay suggests that strategies reducing Gal-9 levels could accelerate reservoir decay. Additionally, the correlations of MIP-3α and IL-6 with HIV kinetics indicate a broader cytokine-mediated regulatory network, hinting at multi-targeted interventions that could modulate HIV reservoir dynamics.