Cefazolin prophylaxis in children undergoing cardiac surgery with the use of cardiopulmonary bypass-is the dosing correct?

Radoslaw JaworskiKatarzyna Dzierzanowska-FangratAgnieszka CzajkowskaBohdan Maruszewski Andrzej Kansy

Published in: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2021)

Direct extrapolation of antibiotic prophylaxis recommendations from adults to children may result in suboptimal antibiotic concentrations. An additional cefazolin dose to ECC priming appears necessary and the dosing should be based on ECC priming volume rather than on the weight of the patient.

Keyphrases

cardiac surgery
young adults
body mass index
physical activity
weight loss
weight gain