Phase II Trial of Response-Based Radiation Therapy for Patients with Localized Germinoma: A Children's Oncology Group Study.

Ute BartelsArzu Onar-ThomasSunita K PatelDennis ShawJason FangusaroGirish DhallMark SouweidaneAashim BhatiaLeanne EmbryChristine L TraskErin S MurphyShannon MacDonaldShengjie WuJames M BoyettSarah E S Leary Maryam FouladiAmar GajjarSoumen Khatua

Published in: Neuro-oncology (2021)

While a failure according to the prospective statistical noninferiority design, this study demonstrated high rates of chemotherapy responses, favorable KM based PFS and OS estimates in the context of reduced irradiation doses and holds promise for lower long-term morbidities for patients with germinoma.

Keyphrases

young adults
palliative care
open label
big data
machine learning
radiation induced
deep learning
placebo controlled
study protocol