Multi-scale Pan-cancer Integrative Analyses Identify the STAT3-VSIR Axis as a key Immunosuppressive Mechanism in Head and Neck Cancer.
Ramachandra KatabathulaPeronne JosephSalendra SinghSongzhu ZhaoBhavna KumarPatricia GauleQuintin PanMatthew OldDavid P TuckVinay VaradanPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
The STAT3-VSIR axis is a potentially significant immuno-modulatory mechanism in oral cavity and ovarian cancers, whose activation is associated with poorer survival and an immune microenvironment marked by decreased CD4 helper T-cell activity. The role of VSIR as a tumor-intrinsic modulator of resistance to immunotherapy warrants further exploration.