Stricturing Crohn's disease single-cell RNA sequencing reveals fibroblast heterogeneity and intercellular interactions.
Pranab K MukherjeeQuang Tam NguyenJiannan LiShuai ZhaoStephen M ChristensenGail A WestJyotsna ChandraIlyssa O GordonSinan LinJie WangRen MaoDouglas CzarneckiCarla RayanPrerna KotakThomas PlesecSamir LalThomas FabreShoh M AsanoKathryn BoundKevin HartChanyoung ParkRobert MartinezKen DowerThomas A WynnShaomin HuNayden NaydenovMartin DecarisScott TurnerStefan D HolubarScott R SteeleClaudio FiocchiAndrei I IvanovKellie M KravarikFlorian RiederPublished in: bioRxiv : the preprint server for biology (2023)
A full-thickness bowel scRNAseq atlas revealed previously unrecognized fibroblast heterogeneity and interactions in CD strictures and CDH11 was validated as a potential therapeutic target. These results provide a new resource for a better understanding of CD stricture formation and opens potential therapeutic developments.