Multilayer fabrication of durable catheter-deployable soft robotic sensor arrays for efficient left atrial mapping.
Varun KashyapAlexandre CaprioTejas DoshiSun-Joo JangChristopher F LiuBobak MosadeghSimon DunhamPublished in: Science advances (2020)
Devices that perform cardiac mapping and ablation to treat atrial fibrillation provide an effective means of treatment. Current devices, however, have limitations that either require tedious point-by-point mapping of a cardiac chamber or have limited ability to conform to the complex anatomy of a patient's cardiac chamber. In this work, a detailed, scalable, and manufacturable technique is reported for fabrication of a multielectrode, soft robotic sensor array. These devices exhibit high conformability (~85 to 90%) and are equipped with an array of stretchable electronic sensors for voltage mapping. The form factor of the device is intended to match that of the entire left atrium and has a hydraulically actuated soft robotic structure whose profile facilitates deployment from a 13.5-Fr catheter. We anticipate that the methods described in this paper will serve a new generation of conformable medical devices that leverage the unique characteristics of stretchable electronics and soft robotics.
Keyphrases
- left atrial
- high resolution
- high density
- atrial fibrillation
- left ventricular
- catheter ablation
- minimally invasive
- mitral valve
- low cost
- left atrial appendage
- robot assisted
- high throughput
- heart failure
- oral anticoagulants
- pulmonary artery
- mass spectrometry
- case report
- vena cava
- venous thromboembolism
- ultrasound guided
- inferior vena cava
- coronary artery
- acute coronary syndrome
- percutaneous coronary intervention
- smoking cessation