MRP1-Dependent Extracellular Release of Glutathione Induces Cardiomyocyte Ferroptosis After Ischemia-Reperfusion.

Genki Ichihara Yoshinori Katsumata Yuki Sugiura Yuta MatsuokaRae MaedaJin EndoAtsushi AnzaiKohsuke ShirakawaHidenori MoriyamaHiroki KitakataTakahiro HiraideShinichi Goto Seien KoYuji IwasawaKazuhisa Sugai Kyohei Daigo Shinya Goto Kazuki SatoKenichi YamadaMakoto SuematsuMasaki Ieda Motoaki Sano

Published in: Circulation research (2023)

Glutathione was released continuously during IR, primarily in an MRP1-dependent manner, and induced ferroptosis. Suppression of glutathione release attenuated ferroptosis and reduced myocardial infarct size following IR.

Keyphrases

cell death
high glucose
left ventricular
diabetic rats
acute myocardial infarction
angiotensin ii
endothelial cells
heart failure
oxidative stress
atrial fibrillation