Advanced glycation endproducts and dicarbonyls in end-stage renal disease: associations with uraemia and courses following renal replacement therapy.
Remy J H MartensNatascha J H BroersBernard CanaudMaarten H L ChristiaansTom CornelisAdelheid GaulyMarc M H HermansConstantijn J A M KoningsFrank M van der SandeJean L J M ScheijenFrank StifftJeroen P KoomanCasper G SchalkwijkPublished in: Clinical kidney journal (2019)
AGEs and dicarbonyls accumulate in uraemia, which is even exaggerated by dialysis initiation. In contrast, KTx markedly reduces AGEs and dicarbonyls. Given their associations with CVD risk in high-risk populations, lowering AGE and dicarbonyl levels may be valuable.